June 23, 2023
Reduction of thyroid radioactive iodine exposure by oral administration of cyclic oligosaccharides
A research group led by Assistant Professor Kodai Nishi of the Atomic Bomb Disease Institute at Nagasaki University, Assistant Professor Shogo Higaki of the Isotope Science Center at University of Tokyo, Associate Professor Masahiro Hirota of the Research Center for Supports to Advanced Sciences at Shinshu University, and Professor Shigeki Ito of the Faculty of Life Sciences at Kumamoto University, has found that oral uptake of α-CD, used as food additive, has an inhibitory effect on the transfer of radioactive iodine to the thyroid gland. It is expected to be applied to many fields such as food, pharmaceuticals, nuclear emergency preparedness, and medicine.
Research Abstract
Alpha-cyclodextrin, a six-d-glucose cyclic oligosaccharide, has several applications in food and pharmaceuticals, but has also been reported to retain iodine in a stable manner for 16 months. Radioactive iodine, which may cause thyroid cancer and hypofunction, must be properly managed. If the absorption of radioactive iodine is suppressed, it can be expected to lead to a reduction in thyroid exposure. This study clarified the inhibition of radioactive iodine absorption by the oral administration of α-cyclodextrin in a murine model using direct measurement of single photon emission computed tomography. The uptake of radioactive iodine into the thyroid gland in mice administered with radioactive iodine and an α-cyclodextrin solution was approximately 40% lower after 24 h. The finding that oral uptake of α-cyclodextrin has an inhibitory effect on the transfer of radioactive iodine to the thyroid gland has potential for application in many fields such as food, pharmaceuticals, nuclear emergency preparedness, and medicine.
Journal Information
Journal: Scientific Reports
Title: Reduction of thyroid radioactive iodine exposure by oral administration of cyclic
oligosaccharides
Author information: Kodai Nishi,† Masahiro Hirota,† Shogo Higaki,† Shinya Shiraishi, Takashi Kudo, Naoki Matsuda and Shigeki Ito
† These authors contributed equally to this work.
DOI: 10.1038/s41598-023-34254-0
URL: https://www.nature.com/articles/s41598-023-34254-0
